Symbol
Name
ID

Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388

Phenotype annotations related to reproductive system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Absent vas deferens	Ovarian carcinoma	Azoospermia	Obstructive azoospermia	Oligozoospermia	Male infertility
Disease(s) Associated with CFTR	Absent vas deferens	Ovarian carcinoma	Azoospermia	Obstructive azoospermia	Oligozoospermia	Male infertility
autosomal recessive congenital bilateral absence of vas deferens
congenital bilateral absence of vas deferens
cystic fibrosis
pancreatic cancer

Mouse Phenotypes

reproductive system phenotype

impaired sperm migration in female genital tract

asthenozoospermia

decreased corpora lutea number

decreased ovary weight

small ovary

abnormal uterine cervix morphology

decreased uterus weight

small uterus

thin uterus

impaired sperm capacitation

transmission ratio distortion

abnormal vas deferens morphology

delayed sexual maturation

decreased ovulation rate

absent estrous cycle

prolonged estrous cycle

female infertility

reduced female fertility

decreased litter size

reduced male fertility

impaired fertilization

Availability

Mouse Genotype

Cftr^tm1Hgu/Cftr^tm1Hgu

Cftr^tm1Kth/Cftr^tm1Kth

Cftr^tm1Unc/Cftr^tm1Unc

Cftr^tm2Hgu/Cftr^tm2Hgu

Cftr^tm3Bay/Cftr^tm3Bay

Cftr^tm3Hgu/Cftr^tm3Hgu

Cftr^tm1Unc/Cftr⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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